On your profile page there will be a section in the top right hand corner that looks like this:

In the picture, settings is circled. You’ll want to click that.
Now look at the top of the column to the right half of the page. You will see three buttons on the top of that. The middle one is Edit Profile. Make with the clicking!

The next page you will be taken to will show you all sorts of options, such as your relationship status, your zipcode, what kinds of contacts you are open to on the site, etc. Make sure you select a location first and foremost. If you don't, your complete profile won't save properly.
Towards the bottom there are a bunch of boxes to fill in. These are all optional About Me type sections. In fact, About Me is one of them. They are all available for you to customize but they start off filled in with some common profile questions. Each of the these boxes actually have two: a skinny one and a larger one. The skinny ones are where you can customize the questions so that your profile will suit you! If you want to ask yourself what you had for breakfast this morning, THIS would be where to do it.
At the bottom underneath all the customizable questions are options for putting your IM screen names, etc. Below that is an Update Profile button. Click that and all of your information will be saved.
NOTE: If you choose to put a homepage address, MAKE SURE you put the http:// in front of the web address or your webpage won't work. This is because the link will think your site is part of Deviant Nation.